BENG 161A Bioreactor Engineering, Fall Quarter, 2007
Inst |
Day |
Date |
# |
Topic |
Reading in Text |
HW Out |
HW Due |
AS |
Th |
9/27/2007 |
1 |
Cloning, expression, and manufacturing human recombinant erythropoietin |
1 |
|
|
JJ |
Tu |
10/2/2007 |
2 |
Chemical Reactions. Mass Action Kinetics. Allosteric Binding; e.g., hemoglobin. |
3.1,3.2 |
#1 |
|
TA |
|
|
3 |
problem solving. |
|
|
|
JJ |
Th |
10/4/2007 |
4 |
Michaelis-Menten, Rapid Equilibrium Assumption. Quasi-Steady State. |
3.3.1, 3.3.2 |
|
|
JJ |
Tu |
10/9/2007 |
5 |
Lineweaver-Burk plot. Enzyme Inhibition: Competitive, Non-competitive, Uncompetitive, Substrate Inhibition. |
3.3.3, 3.3.4 |
#2 |
#1 |
TA |
|
|
6 |
problem solving. Diffusion & Mass Transfer review. |
|
|
|
JJ |
Th |
10/11/2007 |
7 |
Ex-Continuous Stirred Tank Reactor. Immobilized Enzymes. |
3.4.1 |
|
|
JJ |
Tu |
10/16/2007 |
8 |
Diffusional Limitations in Imobilized Enzyme Systems. Dahmkohler Number. |
3.4.2.1 |
|
#2 |
TA |
|
|
9 |
problem solving. Sample problems. Quiz review. |
3.5, 3.6, 3.7 |
|
|
JJ |
Th |
10/18/2007 |
10 |
Effectiveness Factor. |
3.4.2.2 |
|
|
|
Tu |
10/23/2007 |
11 |
Quiz #1 |
|
|
|
TA |
|
|
12 |
problem solving. |
|
|
|
HYM |
Th |
10/25/2007 |
13 |
Tour of Biogen Idec |
|
|
|
HYM |
Tu |
10/30/2007 |
14 |
Cell Growth. Batch Reactors. Quantifying Cell Number and Mass. Monod Model. Yield & Maintenance Coefficients. |
6.1, 6.2, 6.3 |
#3 |
|
TA |
|
|
15 |
problem solving. |
|
|
|
HYM |
Th |
11/1/2007 |
16 |
Substrate-limited Growth. Optimization of Growth. Continuous Culture |
6.3.2, 6.4 |
|
|
HYM |
Tu |
11/6/2007 |
17 |
Scale-up, Operation and Control: Scale-up and its difficulties |
10.2 |
#4 |
#3 |
TA |
|
|
18 |
problem solving-MATLAB for systems of equations. |
|
|
|
HYM |
Th |
11/8/2007 |
19 |
Bioreactor Instrumentation and Control, |
10.3, 10.4 |
|
|
ST |
Tu |
11/13/2007 |
20 |
Process design/flow and industrial practices for commodity scale chemical production |
|
#5 |
#4 |
TA |
|
|
21 |
quiz review |
|
|
|
ST |
Th |
11/15/2007 |
22 |
Medium selection, waste treatment and process economics |
|
|
|
DC & AA |
Tu |
11/20/2007 |
23 |
Ideal Chemostat. Deviations from Ideality. Chemostat with Recycle. Multistage Chemostat. |
9.1-9.3.2 |
|
#5 |
|
|
11/21/2007 |
24 |
no class |
|
|
|
|
Th |
11/22/2007 |
25 |
THANKSGIVING HOLIDAY |
|
|
|
|
Tu |
11/27/2007 |
26 |
Quiz #2 |
|
|
|
TA |
|
|
27 |
Journal Review |
|
|
|
RLS |
Th |
11/29/2007 |
28 |
Fed batch perfusion systems |
9.3.3, 9.3.4 |
#6 |
|
DC & AA |
Tu |
12/4/2007 |
29 |
Product of animal cell culture. Sterilization. Mixed Cell Cultures. |
9.4, 10, 12 |
|
|
TA |
|
|
30 |
review |
|
|
|
DC & AA |
Th |
12/6/2007 |
31 |
Genentech Tour |
|
|
#6 |
|
Tu |
12/11/2007 |
|
Final Exam (7:00pm - 10:00pm) |
|
|
|
Reading in Text: Chapter # in Shuler & Kargi
Inst: Instructor Initials